Endocrine Abstracts

GPR83 is an orphan G-protein coupled receptor (GPCR) and is expressed in thymus and brain. Within the brain GPR83 mRNA is identified at high levels in the hypothalamic arcuate nucleus that is known to control for body weight regulation.Expression of GPR83 in the arcuate nucleus and the protection of GPR83 knock-out mice against diet induced obesity prompted us to investigate GPR83 signaling properties as well as potential interaction with the melanocorti...